's unique poops, Corn poop - Spawns a blue fly every 2 seconds, Flaming poop - Leaves behind fire that damages enemies, Black poop - Creates slowing black creep. See the dedicated Devil room page for more details, Reveals the entire map and shows the icons for every room which has one, This is completely useless if you currently have both the Treasure Map and The Compass, Doubles your current red hearts up to full health, * , the lost item pool, playing, card, white, red, When used, turns all pickups, chests and non-boss enemies in the room into Bombs, UNLOCK: Unlock this item by getting a 3 win streak, When used, turns all pickups, chests and non-boss enemies in the room into Coins, UNLOCK: Unlock this item by defeating The Lamb in under 20 minutes, When used, turns all pickups, chests and non-boss enemies in the room into Keys, UNLOCK: Unlock this item by defeating The Lamb without taking hearts, coins and bombs, When used, turns all pickups, chests and non-boss enemies in the room into Hearts, UNLOCK: Unlock this item by defeating any floor after Basement I with only half a heart of health (works as The Lost), Teleports you to the Devil Deal Room on the current floor, When used, instantly kills you and spawns 10 pickup on the floor, Each of the 10 things spawned can be any type of consumable or sometimes a pedestal item (up to a maximum of 3 pedestal items), Any pedestal item created by Suicide King will be related to the room where it was used, meaning that using it in the Angel room will spawn Angel room items, UNLOCK: Unlock this card by beating Challenge #7 (Suicide King), UNLOCK: Unlock this card by defeating Mega Satan as Tainted Magdalene, A card which can be thrown as a projectile directly infront of Isaac, instantly killing anything it hits, including most bosses, If thrown at a multi-phase boss with multiple forms such Satan, Mega Satan or Hush it will only kill that particular phase of the boss, If thrown at a multi-phase boss that works from a single health bar such as Isaac, ??? This works with all normal pickups, including cards, runes, chests and trinkets. Gives Isaac a little portal familiar, that moves across the screen as you're firing, The portal will suck up any consumables and trinkets it travels over, causing it to become larger and deal more contact damage, When the portal sucks up 4 pickups, it turns into a portal that can be used to teleport to unexplored rooms around the floor. Based on the Steam Workshop mod created by Ratlah, UNLOCK: Unlock this item by sleeping in 10 different beds, When used, this item will sacrifice up to 2 of your familiars (chosen at random), and spawn a random Devil Room item for each familar sacrificed this way, In addition to the familiars, any blue flies or spiders will be converted to 1 coin each, If Guardian Angel, Sworn Protector, or Seraphim is sacrificed, Satan will be extra happy and reward you with 2 black hearts, Incubus won't be sacrificed if you're playing as Lilith, If used while you have no familiar, this item will do nothing and won't consume the item, Added as part of the Afterbirth+ Booster Pack #5. How do you unlock Godhead? (Blue baby), *, dead, blue, face, fates reward, fate reward, A familiar chest that follows Isaac and has a 25% chance to drop a pickup after clearing a room, Possible drops include hearts, coins, bombs, key, pills, card, runes, batteries, trinket, UNLOCK: Unlock this item by beating Greed Mode with Isaac, Item Pool: Item Room, Greed Mode Item Room, Beggar, An orbital angel which does 7 contact damage per tick and blocks shots, The angel will attract bullets towards it and block them, Sworn Protector will drop an eternal heart if it blocks 10 shots in one room. With the nerf to the Devil Room pool quality overall, this item is the strongest new addition to that pool. I'm sure this will help a lot of new players. Every challenge you beat unlocks an item on that save file. This means if you roll into The Lost, changing back to another character will leave you with only 1/2 of a soul heart, Cannot turn you into a character that isn't unlocked yet, Also includes Lazarus II (Lazarus' revived form) and Dark Judas (effect of Judas' Shadow), It's also possible that this item will pick the same character, making it seem like nothing happened, *, grey, gray, black, remote, zapper, changer, building, A one time use item that when used will explode all objects (i.e. UNLOCK: Unlock this item by defeating challenge #36 (Scat Man), When used, places a sword directly above Isaac's head and while active, will spawn an extra item for every item pedestal spawned, After getting hit once with the item activated, at any time without warning, the sword may fall, instantly killing Isaac regardless of his health, After being hit the sword has a 1/10000 chance every 4 frames to fall. The creep deals 2 damage per tick while enemies stand in it, Lazarus' revived form (Lazarus II) respawns with this item, * item room, treasure room, item room pool, blood drop, red blood, drip, Gives Isaac a guaranteed devil or angel room on every floor that they can appear, even if you have already beaten the boss and it didn't show up originally, Taking the Goat Head (or any other item) in a Devil Deal bars you from encountering Angel Rooms naturally. Of all the tear replacer effects, I find that this isn't the strongest one overall and it's a bit tough to use, plus it overrides literally everything else. Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? ?, Satan and The Lamb as Tainted Samson, When taking damage you have a chance to explode and deal 185 damage to all enemies around you (Same damage as a Mr. Mega bomb), UNLOCK: Unlock this trinket by defeating Mother as Tainted Samson, Familiars follow Isaac's exact movements, (similar to how Jacob & Esau work) instead of following loosely like they usually do, Holding the drop button (Ctrl on Steam version) causes them to stop moving, Doesn't affect some familiars with specific movement patterns, e.g. Also the hit detection has been improved - Technology fires in a straight line, * item room, treasure room, item room pool, silver, gray, grey, red, machine, Tears Down significantly (Tear delay * 2.1 + 3), Synergizes well with a lot of tear effects - e.g. white, square, When used, you have a chance of getting one of the three following effects: Treasure Map (floor layout), Compass (map icons) or Blue Map (secret room locations), REPENTANCE - Book of Secrets now avoids giving mapping effects that the player already has. Repentance introduces a whole new mechanic of Red Rooms - extra rooms attached to the current floor. The effect triggers again 30 seconds after use and again 60 seconds after use, Something's wrong - Spawns a pool of black creep beneath Isaac, Vurp! . Any subsequent hits give +0.4 Tears Up and will ignore the normal fire rate cap, Greatly decreases damage (x0.33 damage multiplier), Individual tears gain random worm effects (e.g. hearts, keys, bombs, coins, pills, cards, trinkets, batteries etc, After the first drop, he has a 67% chance to drop a pickup after 3 coins and a 33% chance to drop a pickup after 4 coins, Bum friend also has a chance to spawn items from the Beggar Item Pool, Counts as 1 of 3 bum items needed towards the Super Bum transformation, * item room, treasure room, item room pool, baby, pink, Item Pool: Devil Room, Curse Room, Red Chest, Gold/Stone Chest, * curse room pool, red chest pool, red chest item pool, golden chest pool, gold chest pool, devil pool, devil room pool, devil deal, dead, cat, grey, gray, guppy head, guppys head, Taking an eternal heart to the next floor or collecting two on the same floor gives you an extra heart container, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Be warned though, Mom's leg can also stomp and hurt Isaac too! Each room is locked to a specific trinket effect, meaning if you exit and re-enter a room, that specific room will always have the same effect. When an enemy touches the halo for couple of seconds, a beam of light will come down and deal a burst of damage to it, The triggered beam also fires in all 4 cardinal directions, dealing damage to anything it touches, Every time Isaac takes damage, the halo grows slightly bigger up to a maximum of 10 times. This will heal red hearts and then give soul hearts up to a total of 6. This includes damage you deal, and environmental damage they take e.g. as Bethany, Gives you a random syringe effect every room, The effect can be The Virus, Roid Rage, Speed Ball, Experimental Treatment, Synthoil, Euthanasia or Growth Hormones, Placed bombs explode after 0.66 seconds instead of the usual 1.5 seconds, This was called Exploded Firecracker in Antibirth, Farts produced by Isaac or familiars will be twice as large, Chance for enemies to burn when entering a room, The chance for this effect to activate is effected by your Luck stat, This includes key blocks and golden chests, Pickups left on current floor will appear in the starting room of the next floor, up to a maximum of 4 pickups, Active items will be rerolled upon using them, Using with Book of Virtues will only reroll the item the book is holding, Has no effect with Notched Axe due to how its durability works, UNLOCK: Unlock this trinket by defeating Mother as Eden, Random luck-based tear effects have an extra chance of occurring, The additional chance is effectively +3 Luck Up, Picking up red hearts now has a high chance to spawn 1-4 blue attack spiders, instead of giving you health back, This effect also works while fully healed, giving a guaranteed chance of getting spiders, While missing any red health the chance for spiders is less, Works for characters that don't use red health, which always gives you spiders, Hearts in Shops can be converted into spiders for free, Gives your familiars improved rate of fire while held, In Antibirth this trinket was called Song of the Siren, UNLOCK: Unlock this trinket by bombing the skull left by The Siren boss after her death, While held at the start of each floor, this trinket spawns four wisp familiar orbitals around Isaac, These wisps are the same as the ones created by the Book of Virtues item, UNLOCK: Unlock this trinket by beating the Boss Rush as Bethany, Your active item no longer gains charges, but battery drops become much more common, UNLOCK: Unlock this trinket by blowing up 10 Battery Beggars, Tears that miss enemies will redirect themselves and travel 90 degrees towards enemies, Tears must be roughly 2 tiles or closer to activate this effect, +10 Luck while held, but the trinket is destroyed when damage is taken, Blood donation machines, Curse Rooms and Sacrifice Rooms wont destroy it, Taking a hit and activating Holy Mantle won't destroy it, Can be dropped in order to avoid breaking it, This trinket is automatically given to you after clearing 3 bosses without taking damage, Treasure Rooms are replaced with Red Treasure Rooms, which contain a deal with the devil in place of a regular item pedestal, If an item room has not yet been entered, it can be transformed to either a regular or Red Treasure Room by picking up or dropping this trinket before entering, Does not affect the mirrored treasure room in Downpour II, UNLOCK: Unlock this trinket by defeating Mother as Azazel, Every time you pick up a coin, you have a small chance to gain 1 bar of charge on your active item, The chance for this effect to happen is 1/6th of the value of the coin picked up, Can only activate once per coin collected, In Antibirth this trinket was called Electric Penny, UNLOCK: Unlock this trinket by donating to a battery beggar until he pays out with an item 5 times, While held, your familiars will now orbit around Isaac instead of following behind him, Activates your active item just before damage would be taken, It doesn't activate for free - the charges are used up as normal if this effect activates. with Brimstone you get 4 lasers, Counts as 1 of 3 spider items needed towards the Spider Baby transformation, * item room, treasure room, item room pool, green, black, +2 Damage Up for tears fired from Isaac's left eye, If playing as Cain or you have an item which modifies which eye you fire tears from, each shot has a 50% chance to do +2 Damage, * item room, treasure room, item room pool, poison, green, brown, bottle, jar, danger, Gives Isaac an eye companion that floats around the room and deals 8 damage per tick on contact with enemies, Damage from Isaac's left eye deal roughly +35% damage, * item room, treasure room, item room pool, red, white, When you take damage, this item recharges one room's worth of charge to your spacebar item, For example, with the D6 you would need to take damage 6 times to fully recharge it, * angel room pool, god room pool, angel room item, shop room pool, shop item pool, Using active items gives a damage up that scales with the charge time, ??? - When used, shoots an Ipecac explosive shot. You still take damage however when using Blood Donation machines and Devil Beggars, *, spikes, spikey, spike rock, greyhost, grey host, Causes all pedestal items to show up as rotating items, that swap every 1 second between the original spawned item and a HP up item. This doesn't work with The Lost characters, While in a room with enemies, red cracks will appear on the floor in random locations, Walking over the crack spawns a white soul familiar, that launches itself into the nearest enemy, exploding and dealing double your tear damage to everything near it, Cracks will keep appearing but only one can exist in the room at a time, UNLOCK: Unlock this item by defeating challenge #38 (Baptism by Fire), While held, this item spawns a familiar that can be moved around using the arrow keys and deals 1.5 damage per tick to any enemies it touches, When activated, you teleport, swapping places with wherever Stitches was positioned, Teleporting next to fires will extinguish them (including blue fires) and on top of shopkeepers will destroy them (gives +10% devil/angel room chance as normal), If used while stitches is on top of an enemy, it can be used to telefrag enemies, dealing x3.5 your damage + 40, Can be used to enter/exit Curse Rooms for free by teleporting infront of the door while holding the direction key to move in immediately. The second knife piece is on the second floor of the Mines. Part Two Second Knife Piece. When used, this card drops all of your hearts (including non-red hearts), coins, keys and bombs on the floor, This effect is done in the most efficient way possible - e.g. Happens a total of 3 times over 30 seconds, ??? Deals 45 damage to enemies it lands on. the lost item pool, cat, bone, pink, grey, gray, guppys paw, guppy paw, Gives a 1/3 chance for room clear rewards to become a normal or locked chest, and a 1/3 chance to reward nothing at all, Doesn't affect coins dropped after waves in Greed Mode, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, 2. 0 share; Share; How to create custom challenges in the Binding of Isaac. communion, the lost item pool, circle, cross, white, yellow, +0.04 Damage Up for every coin you currently have, At 99 coins this item gives +3.96 Damage Up, +0.04 per coin is the amount added before the damage formula is calculated, as this is the only way to show a consistent amount of damage given. If you have PhD it will only increase one stat, Can be used multiple times, but every time you use it, it has a chance to disappear, The Gold Pill can spawn as a Horse Pill, which then causes it to give random Horse pill effects, UNLOCK: Unlock this by defeating Mega Satan as Tainted Cain, Horse Pills rarely spawn as larger versions of normal pills with more powerful effects, Items that synergize with pills also have the same effect with Horse pills, In general, the effect of a Horse Pill is double the effect of a normal pill i.e. I included Stairway in this list because this item is their strongest (and relatively easiest) unlock - it wins runs on its own, since the shop provides you with additional Angel items, Angel statues, and beggars to bomb even more Angel/Devil Rooms. shop item pool, x, paper, Makes all of Isaac's familiars stronger and bigger, Causes most familiars to deal double damage, Has no effect on most familiars that scale with Isaac's tear damage, * key master pool, key beggar pool, key judgement pool, shop room pool, shop item pool, red, heart, UNLOCK: Unlock this item by defeating Isaac as Jacob & Esau. Time is the essence", "Sleeping gatekeepers will need to be awoken with a loud sound", UNLOCK: Unlock this card by beating Challenge #11 (Glass Cannon). if you have 99 coins it will create 3 x Quarters, 2 Dimes and 4 Pennies. Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation. Those tears will cause the same effect if they happen to hit other enemies, Effects that replace your tears such as Brimstone simply have a chance to apply this effect, Any enemies that come within close range of Isaac will become feared, which causes them to flee, When used, this item takes away 5 of your coins and gives a +1.2 Damage Up that lasts for the current room, Can stack as many times as you want. Each secret room contains a beam of light, that gives half a soul heart, and a Tears Up for the rest of the floor. red, bolt, cupid arrow, cupids arrow, When used, fires a high damage laser in a straight line across the room in a similar way to Brimstone, The laser deals damage equal to double your tear damage. This is decided by whatever you have the least of. Tap the drop button to cycle between each one, All future pill drops will now instead become cards, * shop room pool, shop item pool, packet, deck, brown, orange, Allows for 2 pills to be held. The chance for a Red Room to unlock increases as you pick up more Crystal Keys. ?, Soul of the Lost, 4 rooms: Rune of Ehwaz, Rune of Perthro, Black Rune, Soul of Isaac, Soul of Eve, Soul of Eden, Soul of the Forgotten, Soul of Jacob and Esau, 6 rooms: Rune of Dagaz, Soul of Samson, Soul of Azazel, Soul of Apollyon, Soul of Bethany, 12 rooms: Rune of Jera, Soul of Lilith, Soul of the Keeper, Tears have a chance to fire a fungus tear that sticks to enemies. in shops or devil rooms), The only way to survive the falling sword is either through extra lives, by using items that would make you invincible, such as Gnawed Leaf or playing as The Lost. After a few seconds, the crosshair will disappear, and the Ghost will do certain things based on what you targeted: Items, pickups, trinkets: Brings them to Isaac. ?, Satan and The Lamb as Tainted Eden, Each brand new room, this trinket has a chance to transform into a copy of a random passive item, which gives you the effect for the duration of this room, UNLOCK: Unlock this trinket by defeating Mother as Tainted Eden, Gives a small chance to spawn a friendly Bony when clearing a room, which will throw bones at enemies until it takes enough damage to die, Can be either the regular white Bony or the black variant, UNLOCK: Unlock this trinket by defeating Isaac, ?? On this floor, look in all the rooms for three yellow buttons, and hit them to press them. I'm here to provide a little direction as to the best unlocks to go for first. red, pink, broken, Better chance to win while gambling at the Shell Game and Fortune Telling Machine, Higher chance to get a random drop after clearing a room, REPENTANCE - Lucky Foot now guarantees positive pill effects, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, starting, pink, white, yellow, A target is placed on the floor which can be controlled. While the item has a chance to do nothing, there is no negative effect from using it. Isaac takes a full heart if hurt by Blood Puppy and it drops a full red heart for every 10 enemies it kills. Unfortunately, some of these unlocks are obtainable while beating Mother and currently on PS4, it does happen that the game will crash while entering the fight. The new Angel Room items and buffs in this DLC tilt the meta towards going for Angel Rooms, especially since they're guaranteed if you don't enter your first Devil Room. If you have 1 or less heart containers, this pill becomes Health Up, Hematemesis - Empties all but one red heart container and spawns 1-4 red hearts on the floor. All your items and consumables are temporarily removed while in the abandoned mine, The room to access Knife Piece 2 only appears if you have Knife Piece 1 already, You can skip pressing the 3 yellow buttons if you have the ability to fly and have 2 bombs to force open the door, When combined with Knife Piece 1, can be used to stab the fleshy door in the Mausoleum II, which then leads to the Corpse floor and the Mother boss, This is a one time use item that teleports you to an alternate floor, which contains every single item in the game, The items are spread between several different rooms all on pedestals. For everything it increases by 1 coin * the number of purchases, The max price of an item is always 99c with this item, Works with Keeper's Box and the Member Card extra shop, Most spider enemies no longer target or deal contact damage to Isaac, This is very similar to a Skatole for spiders instead of flies, Continuously firing or charging tears for 3 seconds causes Isaac to fart and drop a Butt Bomb, Only 1 Butt Bomb can be dropped per charge, so you'll need to stop firing then start again to drop another one, Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time, *, yfront, y-front, underpants, underwear, white, grey, gray, no 2, number two, number 2, no two, Transforms Isaac's tears into a wide arc shape which doubles their size and hitbox, *, flat, white, grey, gray, blue, drip, water, eyes, This item turns all doors that require a key into doors which need a coin to enter instead, This affects shops, item rooms, libraries, double locked doors, key blocks, chests and other key doors, Changes the appearance of doors and objects that this item works on to show a coin slot instead of a keyhole, Item Pool: Shop, Greed Mode Item Room, Greed Mode Shop, *, grey, gray, metal, slot, rectangle, silver, Gives you a random item at the start of your next run (You need to start a fresh run to receive the item), Important progression items such as Key Pieces or the Mom's Shovel pieces cannot be given by Eden's Blessing, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eden, When used, can be thrown at enemies to capture them (similar to a Pok Ball), After capturing an enemy, the next use of the Friendly Ball will re-spawn the same enemy as a friendly companion which will attack other enemies, The companion will persist between rooms and floors until it dies by taking enough damage, Walking over the thrown ball after capturing an enemy will immediately recharge it, *, pokemon, grey, gray, blue, deathstar, circle, When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head, Luck-based items such as Holy Light are applied to each tear individually, Gives Isaac a familiar Gurdy that will charge around the room dealing contact damage to enemies, The Gurdy is charged by holding down the fire button and letting go. 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